Synonyms: PPI-0903 | TAK-599 | Teflaro® | Zinforo®
ceftaroline fosamil is an approved drug (FDA (2010), EMA (2012))
Compound class:
Synthetic organic
Comment: Ceftaroline fosamil is a fifth-generation cephalosporin prodrug which is hydrolysed to the active form, ceftaroline, in vivo. It has anti-MRSA activity [1]. Ceftaroline was removed from the World Health Organization's List of Essential Medicines in 2019.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
References |
1. Duplessis C, Crum-Cianflone NF. (2011)
Ceftaroline: A New Cephalosporin with Activity against Methicillin-Resistant Staphylococcus aureus (MRSA). Clin Med Rev Ther, 3. [PMID:21785568] |
2. Ge Y, Biek D, Talbot GH, Sahm DF. (2008)
In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. Antimicrob Agents Chemother, 52 (9): 3398-407. [PMID:18625769] |
3. Jacobs MR, Good CE, Windau AR, Bajaksouzian S, Biek D, Critchley IA, Sader HS, Jones RN. (2010)
Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. Antimicrob Agents Chemother, 54 (6): 2716-9. [PMID:20308374] |