Synonyms: cannabidiolic acid methyl ester | CBDA-ME | HU580
Compound class:
Synthetic organic
Comment: HU-580 (cannabidiolic acid methyl ester; CBDA-ME) is a stable synthetic analogue of the naturally occurring phytocannabinoid, cannabidiolic acid (CBDA ) [1]. HU-580 has been shown to enhance maximal agonist activation of 5-HT1A receptors in a rat model, and produces anti-nausea and anti-anxiety effects which align with the biological profile reported for CBDA. The compound has efficacy in a rat model of peripheral neuropathic pain when administered at an early stage post-sciatic nerve surgery [2]. Interestingly this effect is only observed in male rats, indicating potential sexual dimorphism in this response.
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References |
1. Pertwee RG, Rock EM, Guenther K, Limebeer CL, Stevenson LA, Haj C, Smoum R, Parker LA, Mechoulam R. (2018)
Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT1A receptor-mediated suppression of nausea and anxiety in rats. Br J Pharmacol, 175 (1): 100-112. [PMID:29057454] |
2. Zhu YF, Linher-Melville K, Niazmand MJ, Sharma M, Shahid A, Zhu KL, Parzei N, Sidhu J, Haj C, Mechoulam R et al.. (2020)
An evaluation of the anti-hyperalgesic effects of cannabidiolic acid-methyl ester in a preclinical model of peripheral neuropathic pain. Br J Pharmacol, 177 (12): 2712-2725. [PMID:31981216] |