Synonyms: example 108 [US9655900B2] | TAK-931 | TAK931
Compound class:
Synthetic organic
Comment: Simurosertib (TAK-931) is an oral Cdc7 (cell division cycle 7-related protein kinase) inhibitor that is being developed by Millennium Pharmaceuticals/Takeda for potential antineoplastic activity in CDC7-overexpressing tumour cells [3]. Cdc7 is a serine/threonine kinase and cell division cycle protein. Simurosertib sensitizes tumour cells to DNA-damaging chemotherapies by functioning to disrupt the cells' ability to recover from DNA damage [2].
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References |
1. Homma M, Miyazaki T, Oguru Y, Kurasawa O. (2017)
Heterocyclic compound. Patent number: US9655900B2. Assignee: Takeda Pharmaceutical Co Ltd. Priority date: 17/02/2010. Publication date: 23/05/2017. |
2. Iwai K, Nambu T, Kashima Y, Yu J, Eng K, Miyamoto K, Kakoi K, Gotou M, Takeuchi T, Kogame A et al.. (2021)
A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery. Sci Adv, 7 (21). DOI: 10.1126/sciadv.abf0197 [PMID:34020950] |
3. Kurasawa O, Miyazaki T, Homma M, Oguro Y, Imada T, Uchiyama N, Iwai K, Yamamoto Y, Ohori M, Hara H et al.. (2020)
Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent. J Med Chem, 63 (3): 1084-1104. [PMID:31895562] |