Synonyms: compound 26 [PMID: 26235950] | RN9893
Compound class:
Synthetic organic
Comment: RN-9893 is an orally-bioavailable, selective inhibitor/antagonist of the TRPV4 ion channel [1]. It inhibits the channel activity of the human, rat and murine variants of TRPV4, and is selective for TRPV4 compared to related TRP channels, including TRPV1, TRPV3 and TRPM8. RN-9893 is therefore an appropriate probe compound for in vivo applications.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Wei ZL, Nguyen MT, O'Mahony DJ, Acevedo A, Zipfel S, Zhang Q, Liu L, Dourado M, Chi C, Yip V et al.. (2015)
Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg Med Chem Lett, 25 (18): 4011-5. [PMID:26235950] |