fosmidomycin

Ligand id: 9739

Name: fosmidomycin

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 107.88
Molecular weight 183.03
XLogP -2.24
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Guide to Malaria Pharmacology Comments
Fosmidomycin is under clinical development as a treatment for uncomplicated P. falciparum malaria. Fosmidomycin provides effective initial clearance of asexual blood stage parasites but concerns have arisen regarding recrudescence rates when the compound is used as a monotherapy in the treatment of uncomplicated P. falciparum malaria [2].

Potential Target/Mechanism Of Action: Fosmidomycin is believed to block the non-mevalonate (MEP) pathway of isoprenoid precursor biosynthesis by inhibiting the second enzyme in the pathway, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) [1].