azithromycin

Ligand id: 6510

Name: azithromycin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 14
Hydrogen bond donors 5
Rotatable bonds 7
Topological polar surface area 180.08
Molecular weight 748.51
XLogP 1.89
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Guide to Malaria Pharmacology Comments
Azithromycin has been investigated as a potential treatment for uncomplicated P. falciparum or P. vivax malaria but does not provide an advantage over current therapies [3].

Potential Target/Mechanism Of Action: As the precise mechanism of action of azithromycin in the malaria parasite is not yet known, we do not have a Plasmodium molecular target for this compound. Further information about possible mechanistic insights is provided under the Clinical data tab.