- Guide to PHARMACOLOGY
Compound class: Synthetic organic
Comment: AIM-1290 is the lead compound from a novel series of thiazole-containing amides that are potent and selective inhibitors of P. falciparum bifunctional farnesyl/geranylgeranyl diphosphate synthase (PfFPPS/GGPPS) .
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Guide to Malaria Pharmacology Comments|
|AIM-1290 is the most promising antimalarial compound derived from a structure-activity relationship (SAR) study of MMV019313, with pharmacokinetic (PK) studies revealing it to have the best in vitro ADME profile and lipophilic efficiency .
Potential Target/Mechanism Of Action: the molecular target of AIM-1290 is P. falciparum bifunctional farnesyl/geranylgeranyl diphosphate synthase (PfFPPS/GGPPS)