MMV009108   Click here for help

GtoPdb Ligand ID: 11463

Synonyms: GNF-Pf-3616
Antimalarial Ligand
Compound class: Synthetic organic
Comment: MMV009108 is a drug-like compound that was chosen as one of the chemotypes included in the MMV Malaria Box [2]. It is one of three structurally diverse small molecules that have been shown to inhibit P. falciparum Niemann-Pick type C1-related protein (PfNCR1) [1].

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 98.92
Molecular weight 415.14
XLogP 4.88
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES CCN(S(=O)(=O)c1ccc(cc1)c1csc(n1)Nc1ccc(c(c1)C)C)CC
Isomeric SMILES CCN(S(=O)(=O)c1ccc(cc1)c1csc(n1)Nc1ccc(c(c1)C)C)CC
InChI InChI=1S/C21H25N3O2S2/c1-5-24(6-2)28(25,26)19-11-8-17(9-12-19)20-14-27-21(23-20)22-18-10-7-15(3)16(4)13-18/h7-14H,5-6H2,1-4H3,(H,22,23)
Guide to Malaria Pharmacology Comments
Potential Target/Mechanism Of Action: a chemical genetics approach has provided evidence suggesting that MMV009108 targets P. falciparum Niemann-Pick type C1-related protein (PfNCR1).