Compound class:
Synthetic organic
Comment: Methnaridine is a novel benzonaphthyridine antimalarial compound, identified from a structural optimization study of pyronaridine [1].
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. |
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Guide to Malaria Pharmacology Comments |
In addition to rapid and potent activity against the asexual blood stages of the malaria parasite, methnaridine has good oral bioavailability, a long half-life and a low clearance rate [1]. Further preclinical studies, to evaluate the use of methnaridine as part of an artemisinin-combination therapy (ACT), are being carried out. Potential Target/Mechanism Of Action: As the precise MOA of methnaridine is not yet known, we do not have a molecular target for this compound. |