- Guide to PHARMACOLOGY
piperaquine is an approved drug (EMA (2011) in combination with artenimol)
Compound class: Synthetic organic
Comment: Piperaquine is a 4-aminoquinoline antimalarial compound.
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Guide to Malaria Pharmacology Comments|
|Piperaquine is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019). Piperaquine is used in combination with artenimol as a curative treatment for malaria and is one of the artemisinin-based combination therapies (ACTs) recommended in the WHO Guidelines for the treatment of malaria .
Potential Target/Mechanism Of Action: As the precise MOA of piperaquine is not yet known, we do not have a molecular target for this compound. It is thought that piperaquine has a similar MOA to chloroquine, killing the malaria parasite by causing a build up of toxic heme by inhibiting the enzyme that normally converts it to non-toxic haemozoin .