Synonyms: AZD-3582 | AZD3582 | HCT-3012 | NO-naproxen
Compound class:
Synthetic organic
Comment: Naproxcinod is a NO-donating naproxen analogue prodrug. It is the first in a new class of anti-inflammatory and analgesic drugs known as cyclooxygenase-inhibiting nitric oxide donors (CINODs) [2], that are designed to lessen the gastrointestinal (and cardiovascular) side-effects of traditional NSAIDs. The NO released by the prodrug mediates this beneficial effect.
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Immunopharmacology Comments |
Anti-inflammatory and analgesic effects are associated with the naproxen released by this prodrug. |
Immunopharmacology Disease | |||
Disease | X-Refs | Comment | References |
Osteoarthritis |
Disease Ontology:
DOID:8398 |
Naproxcinod has completed Phase 3 clinical trial for OA. | 5 |
Duchenne muscular dystrophy |
Disease Ontology:
DOID:11723 OMIM: 19518854 |
Naproxcinod has orphan drug designation for DMD in Europe and the US. |