itolizumab   Click here for help

GtoPdb Ligand ID: 9421

Synonyms: Alzumab® | T1h
Approved drug Immunopharmacology Ligand
itolizumab is an approved drug (DCGI (India; 2013))
Compound class: Antibody
Comment: Itolizumab is a first in class humanized IgG1 monoclonal antibody targeting T cell CD6. It is being developed by Biocon Limited for its anti-inflammatory potential in autoimmune conditions.
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Immunopharmacology Comments
Itolizumab downregulates CD6-induced T-cell activation, inhibiting the synthesis of pro-inflammatory cytokines by T-helper (Th) 17 cells. However, the presence of CD6 on all T cells, and the lack of clarity around whether CD6 is a positive or negative co-stimulator of T-cell activation, warrants caution regarding the potentially widespread immunomodulatory effects of anti-CD6 therapy.
Immunopharmacology Disease
Disease X-Refs Comment References
Psoriasis Disease Ontology: DOID:8893
Approved drug for chronic plaque psoriasis.