Synonyms: Fagarasterol | Lupeol
Compound class:
Synthetic organic
Comment: Oral administration of Lupeol to dextran sulfate sodium (DSS)-induced colitis mice reduced intestinal inflammation and increased survival. This was associated with decreased expression of M1-related genes and increased expression of M2-related genes. Lupeol ameliorates experimental inflammatory bowel disease, at least in part, through inhibiting M1 and promoting M2 macrophages [2]. Similar results were simultaneously published in a different journal [1]. Note there are many isomers of this structure that can be found using the "same connectivity" operator in the PubChem CID entry.
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Immunopharmacology Disease | |||
Disease | X-Refs | Comment | References |
Inflammatory bowel disease |
Disease Ontology:
DOID:0050589 OMIM: 266600 |
Experimental compound with predicted application in inflammatory bowel diseases. |