IL-37

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Ligands
IL-37 (Human)

GtoPdb Ligand ID: 6149

Synonyms: IL-1ζ | IL-23 | interleukin-1ζ | interleukin-1-related protein (IL1RP) | interleukin-23

Compound class: Endogenous peptide in human, mouse or rat

Comment: IL-37 is an anti-inflammatory cytokine of the innate immune system.

Species: Human

Summary
Biological activity
References
Structure
Immunopharmacology

Immunopharmacology Comments
IL-37 is an IL-1 family cytokine. It is anti-inflammatory. It can activate the interleukin-18 receptor. IL-37 is a key inhibitor of innate immunity, that is involved in mitigating inflammation triggered by TLR ligands and cytokines [2], and is an important suppressor of joint and systemic inflammation, the latter activity suggesting potential for using recombinant IL-37 as an anti-arthritic therapy [1].

Immunopharmacology Comments

IL-37 is an IL-1 family cytokine. It is anti-inflammatory. It can activate the interleukin-18 receptor. IL-37 is a key inhibitor of innate immunity, that is involved in mitigating inflammation triggered by TLR ligands and cytokines [2], and is an important suppressor of joint and systemic inflammation, the latter activity suggesting potential for using recombinant IL-37 as an anti-arthritic therapy [1].