- Guide to PHARMACOLOGY
Synonyms: cholinergic differentiation factor (CDF) | differentiation-inducing factor (DIF) | human interleukin in DA cells (HILDA)
Compound class: Endogenous peptide in human, mouse or rat
Comment: LIF is an IL-6 family cytokine.
|LIF is a Th2-type cytokine expressed by neurons, hepatocytes and kidney and breast epithelial cells. Its expression is upregulated by IL-4 and progesterone, and downregulated by inflammatory mediators including IFNγ.|