IFN-ω   Click here for help

GtoPdb Ligand ID: 4970

Synonyms: interferon alpha-II-1 | interferon omega-1
Immunopharmacology Ligand
Comment: IFN-ω is a type I IFN. In humans, only one functional form has been characterised; however, several pseudogenes are described.
Species: Human
Immunopharmacology Comments
IFN-ω is secreted by leukocytes at the site of viral infection or by tumors. Like other type I IFNs, IFN-ω binds the IFN-α/β receptor (IFNAR), a dimeric receptor that consists of protein chains encoded by the IFNAR1 and IFNAR2 genes, and induces expression of proteins containing ISRE or GAS transcription elements.