- Guide to PHARMACOLOGY
Synonyms: macrophage inflammatory protein 4 | small-inducible cytokine A18
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL18 is a CC family chemokine. There are no rodent homologs of this human chemokine.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|CCL18 is principally a chemokine produced by antigen presenting cells of the innate immune system (e.g. dendritic cells, monocytes, and macrophages), with effects predominantly on the adaptive immune system. CCL18 production is upregulated by cytokines such as IL-10, IL-4 and IL-13, which all drive a T-helper 2 type response, and are more usually associated with humoral immunity or immunosuppression. CCL18 binding to CCR8 induces chemotaxis of Th2 cells, and is competitive with the proviously known CCR8 ligand, CCL1. The biological effects of CCL18 cen be pro-inflammatory or immunosuppressive depending on the tissues, cells and incoming signals involved.|