- Guide to PHARMACOLOGY
Compound class: Endogenous peptide in human, mouse or rat
Comment: CXCL14 is a C-X-C motif chemokine with a broad spectrum of biological activities.
|CXCL14 participates in regulation of immune cell migration and antimicrobial immunity. Expression is inducible in monocytes, B cells, monocyte-derived immature dendritic cells and THP-1 leukemia cells. CXCL14 may play a role in immune surveillance in the skin, and have may antiangiogenic action on cancer cells. Some evidence suggests that it is an endogenous inhibitor of the CXCL12/CXCR4 signalling axis, and this effect can inhibit CXCL12-mediated chemotaxis of CD34+ hematopoietic progenitor cells.. CXCL14 function is reviewed in .|