CXCL13   Click here for help

GtoPdb Ligand ID: 3645

Synonyms: BCA-1
Immunopharmacology Ligand
Comment: CXCL13 is a C-X-C motif homeostatic chemokine that is selectively chemotactic for B cells belonging to both the B-1 and B-2 subsets. It exerts its biological effects via binding to the chemokine receptor CXCR5. CXCL13 expression can be regulated by the lymphotoxin β receptor (LTBR) pathway, and it contributes to ectopic tertiary lymphoid tissue development at sites of chronic inflammation in several autoimmune diseases, for example in the lacrimal and salivary glands of Sjögren's patients [4]. The CXCL13/LTBR axis is considered as a potential therapeutic target in conditions like Sjögren's syndrome. This is evidenced by the development of pharmaceutical agents that block LTBR activity being advanced to clinical trials (e.g. baminercept (BG9924) which is a soluble LTBR-IgG Fc fusion protein [3]).
Species: Human
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Immunopharmacology Comments
CXCL13 is involved in shaping B-cell dynamics to enhance antigen encounter and BCR-triggered B-cell activation [6].
Immunopharmacology Disease
Disease X-Refs Comment References
Sjögren's syndrome Orphanet: ORPHA378
Serum CXCL13 is elevated in patients with SS, compared to healthy controls. Expression of CXCL13 in ectopic lymphoid-like follicles in salivary glands of SS patients has been suggested as a potential disease marker. CXCL13 levels are reduced by blockade of lymphotoxinβ receptor in the NOD mouse model of SS. 1,4-5