- Guide to PHARMACOLOGY
Synonyms: compound 34 [PMID: 30423248]
Compound class: Synthetic organic
Comment: Compound 34 is an exemplar selective and covalent Janus kinase 3 (JAK3) inhibitor that was discovered by Casimiro-Garcia et al. . It was designed such that its cyanamide group directly engages the Cys909 residue in JAK3.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|JAK3 is an anti-inflammatory drug target and there is ongoing pharmaceutical industry interest in the discovery of JAK3-selective inhibitors.|