- Guide to PHARMACOLOGY
Synonyms: DHA | dihydroartemisinin | GNF-Pf-5634
artenimol is an approved drug (EMA (2011) in combination with piperaquine)
Compound class: Natural product or derivative
Comment: Artenimol is the active metabolite of artemisinin and all artemisinin-derived antimalarial compounds.
We show one representation of artenimol here. As with other natural products, there are alternative chemical structures due to the complex stereochemistry.
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
|No information available.|
|Summary of Clinical Use|
|Artenimol is approved by the EMA for use in the treatment of malaria, only as part of an artemisinin-based combination therapy (ACT) with piperaquine (trade name Eurartesim®). The FDA granted Orphan Drug designation for Eurartesim® in 2007 for the treatment of uncomplicated malaria (link to FDA Orphan Drug Designation record here).
The link to extended ADME data provided below is for the combined formulation with piperaquine.
For extended ADME data see the following:
European Medicines Agency (EMA)