sertindole   Click here for help

GtoPdb Ligand ID: 98

Synonyms: Serdolect® | Serlect® | sertindol
Approved drug
sertindole is an approved drug
Compound class: Synthetic organic
Comment: Sertindole is an atypical antipsychotic medication, functioning as a dopamine D2 and serotonin 5-HT2 receptor antagonist.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 39.99
Molecular weight 440.18
XLogP 4.14
No. Lipinski's rules broken 0
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Canonical SMILES Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O
Isomeric SMILES Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O
InChI InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31)
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Summary of Clinical Use Click here for help
Atypical antipsychotic used in the treatment of schizophrenia. Although this drug was withdrawn in some countries due to concerns over cardiovascular adverse effects, some national regulatory authorities maintain approval, such as in Australia where sertindole is indicated only for treatment of patients whose schizophrenia is not responsive to, or who are intolerant of other antipsychotic medicines. This drug is not approved in the US. In October 2001, the EMA lifted a marketing suspension, but imposed restrictions on the approval (click here to view the EMA's summary/review of sertindole's marketing authorisation).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Antagonist at a range of GPCRs, namely dopamine D2 receptors, serotonin 5-HT2A and 5-HT2C receptors and α1-adrenoceptors.