risperidone   Click here for help

GtoPdb Ligand ID: 96

Synonyms: Okedi® | R-64-766 | R-64766 | Risperdal®
Approved drug PDB Ligand
risperidone is an approved drug (FDA (1993), EMA (2022))
Compound class: Synthetic organic
Comment: Risperidone is an atypical antipsychotic drug, functioning as a dopamine D2, serotonin 5-HT2 and α2-adrenoceptor antagonist.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 64.16
Molecular weight 410.21
XLogP 3.73
No. Lipinski's rules broken 0
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Canonical SMILES Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2
Isomeric SMILES Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2
InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
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Summary of Clinical Use Click here for help
Antipsychotic used in the treatment of schizophrenia, manic episodes of bipolar disorder and irritability in autism.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Risperidone displays affinity for a range of receptors across the 5-HT, dopamine, histamine, and adrenoceptor families. Its properties as an antipsychotic are believed to arise from its antagonism of dopamine D2 and 5-HT2A receptors.
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