fluspirilene   Click here for help

GtoPdb Ligand ID: 85

Synonyms: Imap® | MCN-JR-6218 | R-6218 | Redeptin®
Approved drug
fluspirilene is an approved drug
Compound class: Synthetic organic
Comment: Fluspirilene is a long-acting typical antipsychotic drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 35.58
Molecular weight 475.24
XLogP 6.21
No. Lipinski's rules broken 1
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Canonical SMILES Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1
Isomeric SMILES Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1
InChI InChI=1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35)
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Summary of Clinical Use Click here for help
Long acting first generation anti-psychotic drug used to treat schizophrenia. Administered by intramuscular injection. However, there is no information regarding approval for clinical use of fluspirilene on the US FDA website. Individual national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Like the other diphenylbutylpiperidine antipsychotics, this drug's beneficial clinical oucomes likely arise from agonist activity at dopamine receptors.