Synonyms: 13-cis retinoic acid
isotretinoin is an approved drug (FDA (1982))
Compound class:
Synthetic organic
Comment: Isotretinoin is a retinoid type drug ie it is a vitamin A-like molecule. It is the endogenous agonist for retinoic acid receptors (RARs).
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: isotretinoin |
|
No information available. |
Summary of Clinical Use |
Primarily used to treat cystic acne. |
Mechanism Of Action and Pharmacodynamic Effects |
Isotretinoin has a low affinity for retinoic acid receptors (RAR) and retinoid X receptors (RXR), but metabolites may act as agonists of these nuclear receptors [1]. Activation of RAR modulates the expression of genes essential for regulating cell proliferation and differentiation. Isotretinoin may also posess immunomodulatory and anti-inflammatory activities and has been demonstrated to inhibit ornithine decarboxylase, an action likely to decrease polyamine synthesis and keratinization. |
External links |
For extended ADME data see the following: Drugs.com |