levomilnacipran   Click here for help

GtoPdb Ligand ID: 7435

Synonyms: F-2695 | Fetzima®
Approved drug
levomilnacipran is an approved drug (FDA (2013))
Compound class: Synthetic organic
Comment: Levomilnacipran is the active enantiomer of milnacipran. [2]. It is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SNRI).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 46.33
Molecular weight 246.17
XLogP 1.91
No. Lipinski's rules broken 0
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Canonical SMILES NCC1CC1(c1ccccc1)C(=O)N(CC)CC
Isomeric SMILES NC[C@@H]1C[C@]1(c1ccccc1)C(=O)N(CC)CC
InChI InChI=1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/h5-9,13H,3-4,10-11,16H2,1-2H3/t13-,15+/m0/s1
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Summary of Clinical Use Click here for help
Used to treat major depressive disorder [1]. Clinical formulations contain levomilnacipran hydrochloride (PubChem CID 6917778).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Levomilnacipran inhibits reuptake of serotonin and noradrenaline by their respective transporters, SERT (SLC6A4) and NET (SLC6A2). By inhibiting the re-uptake of serotonin and norepinephrine in the CNS, this drug rebalances the levels of these neurotransmitters and increases their activity. This improves symptoms of depression and anxiety.
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