vilazodone   Click here for help

GtoPdb Ligand ID: 7427

Synonyms: EMD-515259 | EMD-68-843 | SB-659746-A | Viibryd®
Approved drug PDB Ligand
vilazodone is an approved drug (FDA (2011))
Compound class: Synthetic organic
Comment: Note that the USAN (United States Adopted Name) refers to the hydrochloride salt which has PubChem CID 6918313.
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View more information in the IUPHAR Pharmacology Education Project: vilazodone

2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 102.29
Molecular weight 441.22
XLogP 3.35
No. Lipinski's rules broken 0
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Canonical SMILES N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2
Isomeric SMILES N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2
InChI InChI=1S/C26H27N5O2/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32)
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Summary of Clinical Use Click here for help
Vilazodone is used in the treatment of major depressive disorder.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
This drug acts as a combined serotonin reuptake inhibitor (SRI) and 5-HT1A receptor partial agonist [1-4].
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