- Guide to PHARMACOLOGY
Compound class: Synthetic organic
Comment: Isolated from a culture of a Streptomyces sp. obtained from a tropical marine sediment .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.|
|Mechanism Of Action and Pharmacodynamic Effects|
|Nahuoic acid A is a selective SAM-competitive inhibitor of SETD8 ; SAM (S-adenyl methionine) is a cofactor for enzymatic activity of many methyltransferase proteins and SAM mimetics bind within the cofactor binding site of the enzyme.|