- Guide to PHARMACOLOGY
Synonyms: GR-43175C | Imigran® | Tosymra® (nasal spray)
sumatriptan is an approved drug (FDA (1992))
Compound class: Synthetic organic
Comment: Sumatriptan is a selective serotonin 5-HT1B/ID receptor agonist.
Marketed formulations contain sumatriptan succinate (PubChem CID 59772).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: sumatriptan
|No information available.|
|Summary of Clinical Use|
|Used in the treatment of acute migraine attacks. Oral, injectable (Zembrace SymTouch®, a pre-filled single-dose, disposable autoinjector) and inhalation (Onzetra Xsail®, sumatriptan powder delivered using the novel XsailTM breath powered delivery device) formulations of sumatriptan succinate are available.|
|Mechanism Of Action and Pharmacodynamic Effects|
|Agonist of 5-HT1B and 5-HT1D receptors. Following binding of sumatripan to these receptors, adenylate cyclase activity is inhibited, increasing intracellular calcium resulting in vasoconstriction and inhibition of sensory nocieptive nerve firing and vasoactive peptide release.|
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)