triflupromazine   Click here for help

GtoPdb Ligand ID: 4330

Synonyms: triflupromazine hydrochloride | Vesprin®
Approved drug
triflupromazine is an approved drug (FDA (1957))
Compound class: Synthetic organic
Comment: Triflupromazine is a phenothiazine class antipsychotic drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 31.78
Molecular weight 352.12
XLogP 5.23
No. Lipinski's rules broken 1
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Canonical SMILES CN(CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F)C
Isomeric SMILES CN(CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F)C
InChI InChI=1S/C18H19F3N2S/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21/h3-4,6-9,12H,5,10-11H2,1-2H3
No information available.
Summary of Clinical Use Click here for help
Used for the management of psychoses, and the control of nausea and vomiting.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Triflupromazine is an antagonist of the dopamine D2 receptor. For an overview of the mechanism of action of triflupromazine, please see the DrugBank link on the Summary tab of this ligand page.