hexamethonium   Click here for help

GtoPdb Ligand ID: 3963

Compound class: Synthetic organic
Comment: An antagonist at nicotinic acetylcholine receptors on sympathetic and parasympathetic ganglia.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 0
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 0
Molecular weight 202.24
XLogP 0.97
No. Lipinski's rules broken 0
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Canonical SMILES C[N+](CCCCCC[N+](C)(C)C)(C)C
Isomeric SMILES C[N+](CCCCCC[N+](C)(C)C)(C)C
InChI InChI=1S/C12H30N2/c1-13(2,3)11-9-7-8-10-12-14(4,5)6/h7-12H2,1-6H3/q+2
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Summary of Clinical Use Click here for help
Hexamethonium was used to treat chronic hypertension, but use has been discontinued. No information regarding international approval status is available.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Hexamethonium acts as negative allosteric modulator of nicotinic acetylcholine receptor activity in sympathetic and parasympathetic ganglia.