clidinium   Click here for help

GtoPdb Ligand ID: 366

Synonyms: Quarzan®
Approved drug
clidinium is an approved drug
Compound class: Synthetic organic
Comment: Clidinium is an antagonist of the muscarinic M1 and M3 acetylcholine receptors. The branded drug Librax® contains clidinium bromide and chlordiazepoxide.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 46.53
Molecular weight 352.19
XLogP 2.97
No. Lipinski's rules broken 0
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Canonical SMILES O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2
Isomeric SMILES O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2
InChI InChI=1S/C22H26NO3/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20,25H,12-16H2,1H3/q+1
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Summary of Clinical Use Click here for help
Used in the treatment of peptic ulcers, irritable bowel syndrome and the relief of abdominal or stomach spasms or cramps. US FDA marketing approval for clidinium (trade name Quarzan®) has been discontinued.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Mechanism of action is thought to be primarily due to inhibition of the muscarinic actions of acetylcholine on M1 muscarinic receptors located postganglionically at parasympathetic neuroeffector junctions.