buspirone   Click here for help

GtoPdb Ligand ID: 36

Synonyms: Buspar® | MJ-9022-1
Approved drug
buspirone is an approved drug (FDA (1986))
Compound class: Synthetic organic
Comment: Buspirone is an anxiolytic psychotropic drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 69.64
Molecular weight 385.25
XLogP 2.38
No. Lipinski's rules broken 0
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Canonical SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Isomeric SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
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Summary of Clinical Use Click here for help
Buspirone is used in the management of anxiety disorders
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Buspirone binds to and inhibits firing of serotonin 5-HT1A receptors and blocks presynaptic dopamine D2 receptors. This combined action suppresses serotonergic activity and enhances noradrenergic and dopaminergic activity.