carbachol   Click here for help

GtoPdb Ligand ID: 298

Synonyms: Carbastat® | Carboptic®
Approved drug PDB Ligand
carbachol is an approved drug (FDA (1972))
Compound class: Synthetic organic
Comment: Carbachol is a cholinergic agonist acting at both muscarinic and nicotinic receptors.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 52.32
Molecular weight 147.11
XLogP -0.97
No. Lipinski's rules broken 0
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Canonical SMILES NC(=O)OCC[N+](C)(C)C
Isomeric SMILES NC(=O)OCC[N+](C)(C)C
InChI InChI=1S/C6H14N2O2/c1-8(2,3)4-5-10-6(7)9/h4-5H2,1-3H3,(H-,7,9)/p+1
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Summary of Clinical Use Click here for help
Used in the treatment of glaucoma and during ophthalmic surgery.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Although the exact mechanism which carbachol lowers intraocular pressure is not known, increased outflow of aqueous humour seems to be likely.