- Guide to PHARMACOLOGY
Ligand id: 2954
View more information in the IUPHAR Pharmacology Education Project: rosuvastatin
Molecular properties generated using the CDK
|No information available.|
|Summary of Clinical Use|
|Used in the treatment of primary hyperlipidemia, mixed dyslipidemia and hypertriglyceridemia.
The US FDA approved marketing of the first generic version of rosuvastatin calcium in May 2016.
|Mechanism Of Action and Pharmacodynamic Effects|
|Competitive inhibitor of HMG-CoA reductase, the enzyme catalysing the rate-limiting step of cholesterol synthesis. Acting primarily in the liver, rosuvastatin decreases hepatic cholesterol concentrations. For a complete overview of the mechanism of action of this drug, please see the entry on DrugBank linked to from this ligand page.|
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)