Ligand id: 2950

Name: cerivastatin

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: cerivastatin

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 99.88
Molecular weight 459.24
XLogP 3.42
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Cerivastatin was used to reduce circulating levels of LDL and total cholesterol, but was withdrawn from the US market as a result of severe/fatal adverse effects.
Mechanism Of Action and Pharmacodynamic Effects
Cerivastatin reduces cholesterol and LDL levels by inhibiting the hepatic production of the sterol precursor mevalonate, via inhibition hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme responsible for conversion of HMG-CoA to mevalonate.