lorcaserin   Click here for help

GtoPdb Ligand ID: 2941

Synonyms: APD-356 | Belviq®
Approved drug PDB Ligand
lorcaserin is an approved drug (FDA (2012))
Compound class: Synthetic organic
Comment: Lorcaserin is a selective, orally available and CNS active serotonin 2C receptor agonist that modulates appetite [2-3,5-6]. Cardiovascular safety in obese/overweight patients was reported by Bohula et al. (2018) [1].
Clinical formulations contain lorcaserin hydrochloride (PubChem CID 11673085).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 12.03
Molecular weight 195.08
XLogP 2.45
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES Clc1ccc2c(c1)C(C)CNCC2
Isomeric SMILES Clc1ccc2c(c1)[C@@H](C)CNCC2
InChI InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1
InChI Key XTTZERNUQAFMOF-QMMMGPOBSA-N
No information available.
Summary of Clinical Use Click here for help
Lorcaserin was approved by the FDA in 2012 as an adjuncttive weight-loss therapy that could be used with caloric restriction and increased physical activity in the management of chronic obesity, in patients with BMI ≥27kg/m2. In February 2019 this approval was terminated and the drug was withdrawn from the US market, because a 5 year safety trial revealed increased cancer occurrence associated with lorcaserin therapy. The increased cancer risk was considered by the FDA to outweigh the drug's clinical benefit.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Lorcaserin is a selective 5-HT2C receptor agonist and acts as an anorectic, achieving weight-loss.
External links Click here for help
For extended ADME data see the following:

Drugs.com