cyproheptadine   Click here for help

GtoPdb Ligand ID: 277

Synonyms: cyproheptidine | Periactin® | Peritol®
Approved drug PDB Ligand
cyproheptadine is an approved drug (FDA (1961))
Compound class: Synthetic organic
Comment: Cyproheptadine is a histamine H1 receptor antagonist, and also antagonizes serotonin receptors.
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 3.24
Molecular weight 287.17
XLogP 4.68
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1
Isomeric SMILES CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1
InChI InChI=1S/C21H21N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-11H,12-15H2,1H3
No information available.
Summary of Clinical Use Click here for help
Used in the treatment of rhinitis, allergic conjunctivitis, urticaria and as an adjunct to adrenaline for therapy of anaphylactic reactions.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The main action of cyproheptadine is to reduce the negative symptoms resulting from histamine receptor activation by endogenous ligand. Cyproheptadine effectively competes with (antagonizes) endogenous histamine for binding at histamine receptors.