triiodothyronine   Click here for help

GtoPdb Ligand ID: 2634

Abbreviated name: T3
Synonyms: 3,5,3'-triodo-L-thyronine | Cytomel® | liothyronine sodium
Approved drug PDB Ligand
triiodothyronine is an approved drug (FDA (1956))
Compound class: Metabolite
Comment: Thyroid hormone receptor agonist
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: t3

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 92.78
Molecular weight 650.79
XLogP 2.9
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help
Canonical SMILES OC(=O)C(Cc1cc(I)c(c(c1)I)Oc1ccc(c(c1)I)O)N
Isomeric SMILES OC(=O)[C@H](Cc1cc(I)c(c(c1)I)Oc1ccc(c(c1)I)O)N
InChI InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
InChI Key AUYYCJSJGJYCDS-LBPRGKRZSA-N
No information available.
Summary of Clinical Use Click here for help
Used to treat patients with hypothyroidism as a replacement or supplemental therapy.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
T3 increases the basal metabolic rate, affects protein synthesis and increases sensitivity to catecholamines including adrenaline.
External links Click here for help