Synonyms: Ikorel® | SG-75
nicorandil is an approved drug (UK (2009))
Compound class:
Synthetic organic
Comment: Nicorandil is an antianginal medication that acts as an adenosine triphosphate (ATP)-sensitive K+ (K(ATP)) channel opener and a nitrate [1].
![]() View more information in the IUPHAR Pharmacology Education Project: nicorandil |
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No information available. |
Mechanism Of Action and Pharmacodynamic Effects ![]() |
Nicorandil has dual properties, acting as a nitrate and as a K+ATP channel agonist. At low plasma concentrations the nitrate action dilates the large coronary arteries, and at high plasma concentrations nicorandil induces K+ATP channel opening which reduces coronary vascular resistance [1]. These actions combine to provide cardioprotective effects. |
External links ![]() |
For extended ADME data see the following: Electronic Medicines Compendium (eMC) |