- Guide to PHARMACOLOGY
Synonyms: amitryptiline | Elavil® | Endep®
amitriptyline is an approved drug (FDA (1961))
Compound class: Synthetic organic
Comment: Amitriptyline is a tricyclic antidepressant (TCA).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: amitriptyline
|No information available.
|Summary of Clinical Use
|Developed as a treatment for major depressive disorder and also used in the treatment of migraine and chronic pain.
|Mechanism Of Action and Pharmacodynamic Effects
|Amitriptyline is a potent inhibitor of serotonin and norepinephrine reuptake, the mechanism thought to underlie the drug's antidepressant activity.
For extended ADME data see the following: