- Guide to PHARMACOLOGY
Synonyms: Cafergot® | Ergomar®
ergotamine is an approved drug (FDA (1960))
Compound class: Synthetic organic
Comment: Ergotamine is an ergot derived alkaloid.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.
|Summary of Clinical Use
|Vasoconstrictor, used in the treatment of acute migraine.
|Mechanism Of Action and Pharmacodynamic Effects
|Ergotamine shares structural similarity with neurotransmitters such as serotonin, dopamine, and epinephrine and is therefore an agonist of several receptors. Ergotamine causes vasoconstriction and inhibits the release of pro-inflammatory neuropeptides which correlate with relief of migraine symptoms.