Synonyms: CCD-1042 | CCD1042 | Ztalmy®
ganaxolone is an approved drug (FDA (2022), EMA (2023))
Compound class:
Synthetic organic
Comment: Ganaxolone is a synthetic analogue of the neuroactive steroid allopregnanolone (5α-pregnan-3α-ol-20-one). Its anti-seizure effect is likely associated with its activity as a positive allosteric modulator of the GABAA receptor [1,3-4].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Clinical Trials | |||||
Clinical Trial ID | Title | Type | Source | Comment | References |
NCT03572933 | Study of Adjunctive Ganaxolone Treatment in Children and Young Adults With CDKL5 Deficiency Disorder | Phase 3 Interventional | Marinus Pharmaceuticals | ||
NCT04391569 | RAndomized Therapy In Status Epilepticus | Phase 3 Interventional | Marinus Pharmaceuticals | ||
NCT01963208 | Phase 3 Study of Adjunctive Ganaxolone in Adults With Drug-resistant Partial Onset Seizures and Open-label Extension | Phase 3 Interventional | Marinus Pharmaceuticals |