Synonyms: R-115866 | R115866 | Rambazole®
Compound class:
Synthetic organic
Comment: Talarozole (R115866) is a cytochrome P450 CYP26 inhibitor. It was investigated for clinical efficacy as a treatment for cutaneous inflammation, including psoriasis.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Summary of Clinical Use |
Talarozole progressed to phase 2 evaluation in acne [2] and psoriasis [3]. |
Clinical Trials | |||||
Clinical Trial ID | Title | Type | Source | Comment | References |
NCT00716144 | Dose Ranging Study of the Safety and Efficacy of R115966 in Plaque Psoriasis | Phase 2 Interventional | GlaxoSmithKline | ||
NCT00725439 | An Open Label Trial to Assess the Safety and Efficacy of Oral R115866 in the Treatment Facial Acne | Phase 2 Interventional | GlaxoSmithKline |