Synonyms: MK7622
Compound class:
Synthetic organic
Comment: MK-7622 is a high cooperativity positive allosteric modulator of the M1 muscarinic acetylcholine receptor (M1R) [1-3]. Clinical development of MK-7622 as a therapy for neurological and cognitive disorders was terminated at Phase 2.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Summary of Clinical Use |
MK‐7622 was advanced to clinical trial in patients with Alzheimer's disease to evaluate its potential to improve memory deficit [4]. |
Clinical Trials | |||||
Clinical Trial ID | Title | Type | Source | Comment | References |
NCT01852110 | Efficacy and Safety of MK-7622 as Adjunct Therapy in Participants With Alzheimer's Disease (MK-7622-012) | Phase 2 Interventional | Merck Sharp & Dohme Corp. | MK-7622 had no effect on cognition as an adjunct to acetylcholinesterase inhibitor therapy in this proof-of-concept study. | 4 |