Yoda1   Click here for help

GtoPdb Ligand ID: 9817

Synonyms: Yoda 1
Compound class: Synthetic organic
Comment: Piezo1 channel activator
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 105.1
Molecular weight 353.96
XLogP 3.9
No. Lipinski's rules broken 0
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Canonical SMILES Clc1cccc(c1CSc1nnc(s1)c1cnccn1)Cl
Isomeric SMILES Clc1cccc(c1CSc1nnc(s1)c1cnccn1)Cl
InChI InChI=1S/C13H8Cl2N4S2/c14-9-2-1-3-10(15)8(9)7-20-13-19-18-12(21-13)11-6-16-4-5-17-11/h1-6H,7H2
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Piezo1 Mm Activator Activation 4.8 pEC50 - 1
pEC50 4.8 (EC50 1.71x10-5 M) [1]
Piezo1 Primary target of this compound Hs Activator Activation 4.6 pEC50 - 1
pEC50 4.6 (EC50 2.66x10-5 M) [1]
Ligand mentioned in the following text fields