mucosal addressin cell adhesion molecule 1 
GtoPdb Ligand ID: 9339
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Abbreviated name: MAdCAM-1
Synonyms: addressin | MAdCAM1
Compound class:
Endogenous peptide in human, mouse or rat
Comment: MAdCAM-1 is an extracellular immunoglobulin-like peptide expressed on endothelial cells of intestinal lymphoid tissue [5,7], where it plays a role in gut immune surveillance. It is the ligand for homing receptors (e.g. α4β7 and α4β1 integrins, and L-selectin) on lymphocytes and it acts to direct leukocytes into mucosal and inflamed tissues. The α4β7/MAdCAM-1 interaction is gut-specific. MAdCAM-1 is being investigated as a drug target with potential for management of inflammatory bowel conditions [1,3,6,9]. It has also been identified as a mechanistic target that regulates gut dysbiosis during immune checkpoint blockade cancer treatment [2,4].
The peptide details we provide are for the α isoform, which forms from the longest and predominant transcript. Soluble MAdCAM-1 can be detected in serum.
Species: Human
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| Bioactivity Comments |
| MAdCAM-1 expression is elevated in intestinal biopsies from experimental models of colitis and from patients with Crohn's disease and ulcerative colitis. |
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