Synonyms: ASP8273
Compound class:
Synthetic organic
Comment: ASP8273 is a third generation EGFR inhibitor, targeting T790M / L858R mutants. It is a structural match to example 54 in patent WO2013108754 [1].
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Bioactivity Comments |
ASP8273 inhibits T790M / L858R EGFR with an IC50 of 4.5nM and T790M / L858R/del19 EGFR with IC50 of 3.2nM [1]. |
Selectivity at catalytic receptors | ||||||||||||||||||||||||||||||||||
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