- Guide to PHARMACOLOGY
Synonyms: AG-120 | AG120 | Tibsovo®
ivosidenib is an approved drug (FDA (2018), EMA (2023))
Compound class: Synthetic organic
Comment: Ivosidenib (AG-120) is an orally active, selective inhibitor of isocitrate dehydrogenase 1 (IDH1) , in particular with activity against IDH1 R132H or R132C mutants. It is one of the compounds claimed in Agios' patent WO2013107291, where it is Compound 176 . It is structurally related to AGI-5198 also from Agios.
|Ivosidenib inhibits both R132H and R132C IDH1 mutants with IC50s < 100nM .|
|Selectivity at enzymes|
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