|
|
|
5-HT2A receptor
|
|
|
Hs |
Antagonist |
Antagonist |
8.1 – 9.7 |
pKi |
- |
2,8,16 |
|
⤷ |
pKi
8.1 – 9.7
(Ki 7.94x10-9 – 1.99x10-10 M)
[2,8,16]
|
5-HT2A receptor
|
|
|
Rn |
Antagonist |
Antagonist |
8.6 – 9.0 |
pKi |
- |
4,18 |
|
⤷ |
pKi
8.6 – 9.0
[4,18]
|
5-HT1B receptor
|
|
|
Mm |
Antagonist |
Antagonist |
8.3 |
pKi |
- |
13 |
|
⤷ |
pKi
8.3
[13]
|
α1A-adrenoceptor
|
|
|
Hs |
Antagonist |
Antagonist |
8.2 |
pKi |
- |
24 |
|
⤷ |
pKi
8.2
[24]
|
α1B-adrenoceptor
|
|
|
Hs |
Antagonist |
Antagonist |
8.2 |
pKi |
- |
24 |
|
⤷ |
pKi
8.2
[24]
|
α1D-adrenoceptor
|
|
|
Hs |
Antagonist |
Antagonist |
7.8 |
pKi |
- |
24 |
|
⤷ |
pKi
7.8
[24]
|
5-HT1D receptor
|
|
|
Hs |
Antagonist |
Antagonist |
7.4 – 7.5 |
pKi |
- |
3,12 |
|
⤷ |
pKi
7.4 – 7.5
[3,12]
|
5-HT2C receptor
|
|
|
Hs |
Antagonist |
Antagonist |
6.8 – 7.5 |
pKi |
- |
2,6,8,16 |
|
⤷ |
pKi
6.8 – 7.5
[2,6,8,16]
|
D1 receptor
|
|
|
Hs |
Antagonist |
Antagonist |
6.7 |
pKi |
- |
20 |
|
⤷ |
pKi
6.7
[20]
|
5-HT7 receptor
|
|
|
Rn |
Antagonist |
Antagonist |
6.6 – 6.7 |
pKi |
- |
19 |
|
⤷ |
pKi
6.6 – 6.7
[19]
|
5-HT7 receptor
|
|
|
Mm |
Antagonist |
Antagonist |
6.4 |
pKi |
- |
15 |
|
⤷ |
pKi
6.4
[15]
|
5-HT2B receptor
|
|
|
Hs |
Antagonist |
Antagonist |
6.1 – 6.7 |
pKi |
- |
2,8,10,16,23 |
|
⤷ |
pKi
6.1 – 6.7
[2,8,10,16,23]
|
5-HT7 receptor
|
|
|
Hs |
Antagonist |
Antagonist |
5.9 – 6.5 |
pKi |
- |
1,7,9,21 |
|
⤷ |
pKi
5.9 – 6.5
[1,7,9,21]
|
D5 receptor
|
|
|
Hs |
Antagonist |
Antagonist |
5.6 |
pKi |
- |
20 |
|
⤷ |
pKi
5.6
[20]
|
5-HT2B receptor
|
|
|
Rn |
Antagonist |
Antagonist |
5.4 |
pKi |
- |
22 |
|
⤷ |
pKi
5.4
[22]
|
5-HT1A receptor
|
|
|
Hs |
Antagonist |
Antagonist |
5.0 |
pKi |
- |
14 |
|
⤷ |
pKi
5.0
[14]
|
5-HT5A receptor
|
|
|
Hs |
Antagonist |
Antagonist |
4.7 |
pKi |
- |
17 |
|
⤷ |
pKi
4.7
[17]
|
5-HT1B receptor
|
|
|
Hs |
Antagonist |
Antagonist |
5.2 – 5.4 |
pIC50 |
- |
3,11 |
|
⤷ |
pIC50
5.2 – 5.4
[3,11]
|
|